Tolerance to benzodiazepines like Valium means that users need to continue ramping up the dosage to trigger the same calming effect of gamma-Aminobutyric acid (GABA). The drug had become wildly popular among homemakers, and despite its claim of being a much safer alternative, the drug also came with its set of dangerous effects. “ Mother’s Little Helper,” which was released by The Rolling Stones in 1966, was a dark and catchy song about the drug. It became one of the top-selling drugs of all time, and it wasn’t until a famous The Rolling Stones song that it gained even more popularity. Not only did it have the power to treat epilepsy, muscle spasms, and alcohol withdrawal, it was generally safe. In 1963, an even more potent anxiolytic known as Valium was released the public, possessing a higher dissociation between its sedative and anxiolytic properties. The first benzodiazepine, Librium, promised a new class of potent anxiolytics without fatal adverse events. It quickly became apparent how addictive barbiturates, alcohol, and opioids were when treating these disorders, and was not a feasible option to treat anxiety. It was not until the 1960s when the pharmacotherapy for anxiety disorders became available with an improved safety profile. As medicine began to involve in the mid-20th century, these methods were primarily overtaken by barbiturate drugs. The initial means of treating anxiety consisted of depressant drugs and sedatives such as alcohol, opiates, lithium bromide, and chloral hydrate. It is not a problem tied to a specific socioeconomic background as anyone can be affected at any time. Anxiety and its lack of treatment is a common problem worldwide. Generalized anxiety disorder (GAD) affects more than 40 million people in the United States, and it can range from agoraphobia, panic disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and various others. Valium set the standard for pharmacotherapy relating to potency, onset of action, and safety.Īnxiety disorders have been the most prevalent of all psychiatric ailments. ![]() The purpose of benzodiazepine drugs like Valium is to treat a broad spectrum of central nervous system (CNS) disorders, including anxiety and epilepsy. Diazepam, also known as Valium, is viewed as one of the most successful drugs from the onset of the psychopharmacological revolution that started in the 1950s.
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